Tetanus antitoxin is given prophylactically to persons at the risk of tetanus infection by infected wounds or severe wounds. A dose of 1000 I.U. should be given intramuscularly or subcutaneously and the dose may be doubled or tripled in case of multiple and severe wounds. Prophylactic dose is also given in surgical operations as post operative care.
Along with this passive immunisation, it is advisable to initiate active immunisation with adsorbed Tetanus toxoid.